Structure-Based Design of Antivirals against Envelope Glycoprotein of Dengue Virus
نویسندگان
چکیده
منابع مشابه
Antibodies against the Envelope Glycoprotein Promote Infectivity of Immature Dengue Virus Serotype 2
Cross-reactive dengue virus (DENV) antibodies directed against the envelope (E) and precursor membrane (prM) proteins are believed to contribute to the development of severe dengue disease by facilitating antibody-dependent enhancement of infection. We and others recently demonstrated that anti-prM antibodies render essentially non-infectious immature DENV infectious in Fcγ-receptor-expressing ...
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Dengue virus is an emerging global health threat. The major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. Antibodies that bind but fail to neutralize noncognate serotypes enhance infection. We have determined the crystal structure of a soluble fragment of the envelope glycoprotein E from dengue virus type 3. The structure closely resembles those of E proteins...
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Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformationa...
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Dengue virus is a growing public health threat that affects hundreds of million peoples every year and leave huge economic and social damage. The virus is transmitted by mosquitoes and the incidence of the disease is increasing, among other causes, due to the geographical expansion of the vector's range and the lack of effectiveness in public health interventions in most prevalent countries. So...
متن کاملDengue virus envelope glycoprotein structure: new insight into its interactions during viral entry.
A major step in understanding the molecular interactions that lead to entry of enveloped viruses into their target cells is obtaining structural information on the viral surface glycoproteins at the atomic level. In addition to carrying the main antigenic determinants of the virus, these proteins are responsible for the major steps involved in the entry process, which involve receptor recogniti...
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ژورنال
عنوان ژورنال: Viruses
سال: 2020
ISSN: 1999-4915
DOI: 10.3390/v12040367